Review about PN booster by Dr. Charlie Giroud
Medical Review: Aurorafill PN Booster
for Periorbital Rejuvenation
Reviewer: Dr. Charlie Giroud, MD, FAAD
Specialty: Cosmetic and Medical Dermatology
Date: October 30, 2020
Product: Aurorafill PN Booster (Polynucleotide Solution)
Indication Reviewed:
Treatment of the Infraorbital Area (Under-Eye).
1. Product and Technology Overview
The Aurorafill PN Booster is a specialized injectable formulation utilizing high-concentration
Polynucleotides (PN), derived from purified salmon DNA. The primary mechanism of action
of PN is centered on cellular bio-stimulation. Once injected, PN acts as a scaffold and
signaling molecule, promoting deep hydration and stimulating the local microenvironment,
specifically by:
1. Fibroblast Activation: Enhancing the production of Type I and Type III collagen and elastin.
2. Antioxidant Effect: Scavenging free radicals, which is critical in the thin,
photo-exposed skin of the periorbital region.
3. Tissue Repair: Aiding in the regeneration and normalization of the extracellular
matrix.
The molecular weight and specific viscoelastic properties of the Aurorafill formulation appear
optimized for the delicate nature of the infraorbital skin, minimizing the risk of Tyndall effect
or persistent edema often associated with traditional hyaluronic acid fillers in this area.
2. Clinical Assessment and Efficacy
I have incorporated the Aurorafill PN Booster into my clinical practice for patients presenting
with common infraorbital concerns, primarily:
a) Chronic dark circles (pigmented and vascular)
b) Fine lines and rhytides (crow’s feet and tear trough crepiness)
c) Mild volume deflation or textural atrophy.
Results Observation (Post-Series Protocol)
The standard protocol involves 3 sessions spaced 2-3 weeks apart, with maintenance
treatments every 4–6 months.
● Dark Circles (Vascular/Pigmented): Efficacy in this area has been notable,
particularly in cases where the darkness is attributed to poor microcirculation and
dermal thinness. The bio-stimulatory effect thickens the dermis over time, providing a
better dermal cushion and masking the underlying vasculature. Pigmentary
improvement is slower but observable, likely due to the enhanced antioxidant activity
and improved skin health.
● Fine Lines and Texture: This is where the product demonstrates its strongest
advantage. Patients consistently report a significant reduction in crepiness and fine
lines within 6–8 weeks following the initial treatment series. The increased collagen
and hydration lead to a visibly smoother, tauter skin texture.
● Hydration and Elasticity: Unlike simple mesotherapy, the sustained moisture
retention imparted by the PN matrix is superior. The skin barrier function appears
improved, resulting in a healthier, less translucent appearance under the eye.
3. Safety and Tolerability
The safety profile of the Aurorafill PN Booster, in my experience, is excellent when
administered correctly in the appropriate plane (superficial dermis or sub-dermal).
● Downtime: Minimal. Patients typically experience mild, localized swelling and
erythema for 24–48 hours. Small, transient papules may appear immediately
post-injection but typically resolve within 24 hours. Bruising risk is comparable to
other fine-gauge injectable treatments in this high-vascularity area.
● Adverse Events: No reported instances of severe inflammatory or immunological
responses. The purified nature of the PN appears highly biocompatible.
4. Conclusion and Recommendation
The Aurorafill PN Booster offers a valuable, non-filler alternative for addressing the complex
aging characteristics of the under-eye area. It excels as a dermal restorative agent where
skin quality, fine lines, and textural issues are the primary concern, making it an ideal
treatment for younger patients or those seeking to improve the quality of the skin itself,
rather than solely adding volume.
It is particularly recommended for combination therapy alongside tear trough fillers (when
volume replacement is necessary) to optimize the overlying skin canvas.
Dr. Giroud's Rating: 4.5/5 Stars (Highly Recommended)
Disclaimer: This review is based on clinical experience.